Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 406146
Title Effect of fertilizers on galanthamine and metabolite profiles in narcissus bulbs by 1H NMR
Author(s) Lubbe, A.; Choi, Y.H.; Vreeburg, P.J.M.; Verpoorte, R.
Source Journal of Agricultural and Food Chemistry 59 (2011)7. - ISSN 0021-8561 - p. 3155 - 3161.
DOI https://doi.org/10.1021/jf104422m
Department(s) Flower Bulbs
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) amaryllidaceae alkaloids - nitrogen-fertilizer - gas-chromatography - nmr - growth - metabolomics - leaves
Abstract Narcissus bulbs contain the biologically active alkaloid galanthamine, and Narcissus is being developed as a natural source of the molecule for the pharmaceutical industry. The effect of fertilizer on galanthamine production was investigated in a field study using a 1H nuclear magnetic resonance (NMR) metabolite profiling approach. Galanthamine was quantitated and major metabolites in the bulbs were identified. The application of standard fertilization levels of nitrogen and potassium caused a significant increase in galanthamine as compared to a control. Multivariate data analysis of the 1H NMR data revealed that applying double the standard level of nitrogen fertilizer resulted in production of more amino acids and citric acid cycle intermediates, but not more galanthamine. The results indicated that standard levels of fertilizer currently applied in The Netherlands are sufficient for optimal galanthamine accumulation in the bulbs. This study shows how 1H NMR-based metabolic profiling can provide insight into the response of plant metabolism to agricultural practices.
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