Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 406174
Title Influence of Protein Hydrolysis on the Growth Kinetics of ß-lg Fibrils
Author(s) Kroes-Nijboer, A.; Venema, P.; Bouman, J.; Linden, E. van der
Source Langmuir 27 (2011)10. - ISSN 0743-7463 - p. 5753 - 5761.
Department(s) Physics and Physical Chemistry of Foods
Physical Chemistry and Colloid Science
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) lactoglobulin gels - amyloid fibrils - ph 2 - aggregation - heat - lysozyme - amyloidogenesis
Abstract Recently it was found that protein hydrolysis is an important step in the formation of ß-lactoglobulin fibrils at pH 2 and elevated temperatures. The objective of the present study was to further investigate the influence of hydrolysis on the kinetics of fibril formation. Both the hydrolysis of ß-lactoglobulin and the growth of the fibrils were followed as a function of time and temperature, using SDS polyacrylamide gel electrophoresis and a Thioflavin T fluorescence assay. As an essential extension to existing models, the quantification of the effect of the hydrolysis on the fibrillar growth was established by a simple polymerization model including a hydrolysis step.
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