Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 407139
Title Stochastic modelling of length-dependent telomere shortening in Corvus monedula
Author(s) Grasman, J.; Salomons, H.M.; Verhulst, S.
Source Journal of Theoretical Biology 282 (2011)1. - ISSN 0022-5193 - p. 1 - 6.
Department(s) Biometris (WU MAT)
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) oxidative stress - replicative senescence - cellular senescence - human fibroblasts - human-cells - life-span - accumulation - dynamics - survival - mortality
Abstract It was recently shown that, within individuals, longer telomeres shorten at a higher rate. This explorative study deals with a mathematical model of this process. It is a nonlinear differential equation describing length-dependent decrease that can be linked to a Poisson process. The model also takes in account telomere shortening due to the end replication problem. Parameters are fitted using data from samples of red blood cells of free-living juvenile corvids. The Poisson process can be related to oxidative stress causing DNA strand breaks. The shortest telomeres in a genome are the best predictors of survival, and one can therefore hypothesize on functional grounds that short telomeres should be better protected by some control mechanism in the cellular system. However, the present study shows that such a mechanism is not required to explain length-dependent telomere shortening: agents of telomere shortening such as oxidative stress with a certain strength modeled by a Poisson process with an appropriately chosen parameter suffice to generate the observed pattern
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