Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 407212
Title Pharmacological and toxicological assessment of a potential GnRH vaccine in young-adult male pigs
Author(s) Turkstra, J.A.; Staay, F.J. van der; Stockhofe-Zurwieden, N.; Woelders, H.; Meloen, R.H.; Schuurman, T.
Source Vaccine 29 (2011)21. - ISSN 0264-410X - p. 3791 - 3801.
Department(s) Livestock Research
CVI Infection Biology
LR - Backoffice
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) gonadotropin-releasing-hormone - follicle-stimulating-hormone - advanced prostate-cancer - white-tailed deer - active immunization - testicular function - boar taint - efficient immunocastration - fsh-secretion - male rats
Abstract Active immunization against gonadotrophin-releasing hormone (GnRH) is successfully applied to prevent boar taint in pork. In men, GnRH immunization could be an alternative to hormone therapy in patients with prostate cancer. In this study, a new GnRH vaccine formulation (a modified GnRH peptide conjugate formulated with CoVaccine adjuvant) was investigated for its pharmacological efficacy and safety in young-adult male pigs. Immunization resulted in castrate-like plasma testosterone levels in all treated pigs from week 8 until the end of the study, 30 weeks after the first immunization. Testosterone depletion retarded testes growth, reduced the relative weight of the testes and accessory sex organs, and reduced sperm counts and motility. There was no clinically relevant toxicity. Typical vaccination-related adverse reactions, such as swelling at the injection site and fever, were considered acceptable. We conclude that this GnRH vaccine efficiently and rapidly reduced serum testosterone levels, without inducing chronic toxic effects, and therefore could be applicable in both veterinary and human medicine
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