Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 407298
Title Host Factors Determine Anti-GM1 Response Following Oral Challenge of Chickens with Guillain-Barre Syndrome Derived Campylobacter jejuni Strain GB11
Author(s) Ang, C.W.; Dijkstra, J.R.; Klerk, M.A. de; Endtz, H.P.; Doorn, P.A.; Jacobs, B.C.; Jeurissen, S.H.M.; Wagenaar, J.A.
Source PLoS One 5 (2010)3. - ISSN 1932-6203 - 7 p.
Department(s) ID - Infectieziekten
ID - Dier en Omgeving
Publication type Refereed Article in a scientific journal
Publication year 2010
Keyword(s) miller-fisher-syndrome - lipopolysaccharides - antibodies - infection - colonization - gangliosides - enteritis - exchange - mimicry - rabbits
Abstract Background: Anti-ganglioside antibodies with a pathogenic potential are present in C. jejuni-associated Guillain-Barre syndrome (GBS) patients and are probably induced by molecular mimicry. Immunization studies in rabbits and mice have demonstrated that these anti-ganglioside antibodies can be induced using purified lipo-oligosaccharides (LOS) from C. jejuni in a strong adjuvant. Methodology/Principal Findings: To investigate whether natural colonization of chickens with a ganglioside-mimicking C. jejuni strain induces an anti-ganglioside response, and to investigate the diversity in anti-ganglioside response between and within genetically different chicken lines, we orally challenged chickens with different C. jejuni strains. Oral challenge of chickens with a C. jejuni strain from a GBS patient, containing a LOS that mimics ganglioside GM1, induced specific IgM and IgG anti-LOS and anti-GM1 antibodies. Inoculation of chickens with the Penner HS:3 serostrain, without a GM1-like structure, induced anti-LOS but no anti-ganglioside antibodies. We observed different patterns of anti-LOS/ganglioside response between and within the five strains of chickens. Conclusions: Natural infection of chickens with C. jejuni induces anti-ganglioside antibodies. The production of antibodies is governed by both microbial and host factors.
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