Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 407402
Title beta-Lactam and glycopeptide antibiotics: first and last line of defense?
Author(s) Jovetic, S.; Yang Zhu, Yang; Marcone, G.L.; Marinelli, F.; Tramper, J.
Source Trends in Biotechnology 28 (2010)12. - ISSN 0167-7799 - p. 596 - 604.
DOI http://dx.doi.org/10.1016/j.tibtech.2010.09.004
Department(s) Bioprocess Engineering
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2010
Keyword(s) resistant staphylococcus-aureus - methicillin resistance - antimicrobial resistance - lipid-ii - streptococcus-pneumoniae - vancomycin resistance - crystal-structures - biological cost - united-states - fitness cost
Abstract Most infections are caused by bacteria, many of which are ever-evolving and resistant to nearly all available antibiotics beta-Lactams and glycopeptides are used to combat these infections by inhibiting bacterial cell-wall synthesis This mechanism remains an interesting target in the search for new antibiotics in light of failed genomic approaches and the limited input of major pharmaceutical companies Several strategies have enriched the pipeline of bacterial cell-wall inhibitors examples include combining screening strategies with lesser explored microbial diversity, or reinventing known scaffolds based on structure-function relationships Drugs developed using novel strategies will contribute to the arsenal in fight against the continued emergence of bacterial resistance
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