Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 407411
Title The alpha/beta-Hydrolase Fold 3DM Database (ABHDB) as a Tool for Protein Engineering
Author(s) Kourist, R.; Jochens, H.; Bartsch, S.; Kuipers, R.K.P.; Padhi, S.K.; Gall, M.; Bottcher, D.; Joosten, H.J.; Bornscheuer, U.T.
Source ChemBioChem 11 (2010)12. - ISSN 1439-4227 - p. 1635 - 1643.
DOI http://dx.doi.org/10.1002/cbic.201000213
Department(s) Microbiological Laboratory
Systems and Synthetic Biology
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2010
Keyword(s) antarctica lipase-b - iterative saturation mutagenesis - ligand-binding domain - directed evolution - tertiary alcohols - bacillus-subtilis - fluorescens esterase - server esther - enantioselectivity - family
Abstract Aligning the haystack to expose the needle: The 3DM method was used to generate a comprehensive database of the a/ß-hydrolase fold enzyme superfamily. This database facilitates the analysis of structure–function relationships and enables novel insights into this superfamily to be made. In addition high-quality libraries for protein engineering can be easily designed.
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