Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 407429
Title Multivitamin supplement use and risk of invasive breast cancer
Author(s) Meulepas, J.M.; Newcomb, P.A.; Burnett-Hartman, A.N.; Hampton, J.M.; Trentham-Dietz, A.
Source Public Health Nutrition 13 (2010)10. - ISSN 1368-9800 - p. 1540 - 1545.
Publication type Refereed Article in a scientific journal
Publication year 2010
Keyword(s) multimineral supplements - nutrient intake - national-health - united-states - folate intake - vitamin - fortification - determinants - population - prostate
Abstract Objective: Multivitamin supplements are used by nearly half of middle-aged women in the USA. Despite this high prevalence of multivitamin use, little is known about the effects of multivitamins on health outcomes, including cancer risk. Our main objective was to determine the association between multivitamin use and the risk of breast cancer in women. Design: We conducted a population-based case-control study among 2968 incident breast cancer cases (aged 20-69 years), diagnosed between 2004 and 2007, and 2982 control women from Wisconsin, USA. All participants completed a structured telephone interview which ascertained supplement use prior to diagnosis, demographics and risk factor information. Odds ratios and 95% confidence intervals were calculated using multivariable logistic regression. Results: Compared with never users of multivitamins, the OR for breast cancer was 1.02 (95% CI 0.87, 1.19) for current users and 0.99 (95% CI 0.74, 1.33) for former users. Further, neither duration of use (for >= 10 years: OR = 1.13, 95% CI 0.93, 1.38, P for trend 0.25) nor frequency (> 7 times/week: OR = 1.00, 95% CI 0.77, 1.28, P for trend 0.97) was related to risk in current users. Stratification by menopausal status, family history of breast cancer, age, alcohol, tumour staging and postmenopausal hormone use did not significantly modify the association between multivitamin use and breast cancer. Conclusions: The current study found no association between multivitamin supplement use and breast cancer risk in women.
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