Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 407545
Title Hot Transcriptomics
Author(s) Walther, J.; Sierocinski, P.; Oost, J. van der
Source Archaea : an international microbiological journal 2010 (2010). - ISSN 1472-3646 - 14 p.
DOI https://doi.org/10.1155/2010/897585
Department(s) Microbiological Laboratory
Publication type Refereed Article in a scientific journal
Publication year 2010
Keyword(s) archaeon sulfolobus-solfataricus - dna microarray analysis - turreted icosahedral virus - central carbohydrate-metabolism - heat-shock response - hyperthermophilic archaeon - pyrococcus-furiosus - chromosome-replication - thermococcus-kodakaraensis - methanococcus
Abstract DNA microarray technology allows for a quick and easy comparison of complete transcriptomes, resulting in improved molecular insight in fluctuations of gene expression. After emergence of the microarray technology about a decade ago, the technique has now matured and has become routine in many molecular biology laboratories. Numerous studies have been performed that have provided global transcription patterns of many organisms under a wide range of conditions. Initially, implementation of this high-throughput technology has lead to high expectations for ground breaking discoveries. Here an evaluation is performed of the insight that transcriptome analysis has brought about in the field of hyperthermophilic archaea. The examples that will be discussed have been selected on the basis of their impact, in terms of either biological insight or technological progress.
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