Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 407549
Title Age at which dairy cattle become Mycobacterium avium subsp. paratuberculosis faecal culture positive
Author(s) Weber, M.F.; Kogut, J.; Bree, J. de; Schaik, G. van; Nielen, M. van
Source Preventive Veterinary Medicine 97 (2010)1. - ISSN 0167-5877 - p. 29 - 36.
Department(s) ID - Infectieziekten
Chair Nutrition and Disease
Publication type Refereed Article in a scientific journal
Publication year 2010
Keyword(s) genetic-variation - johnes-disease - ssp-paratuberculosis - antibody-response - immune-responses - diagnostic-tests - infection - calves - susceptibility - polymorphisms
Abstract Age at which cattle become faecal culture positive for Mycobacterium avium subsp. paratuberculosis (Map) can be used as a proxy parameter for age at onset of faecal shedding, which is an important parameter in the control of Map in cattle herds. To investigate the age at becoming faecal culture positive, survival analysis methods were applied. The analyses were carried out on asynchronous interval censored data of faecal culture results of samples collected from 18,979 female Holstein-Frisian cattle in 353 Dutch herds between 1996 and 2002. The data were analysed with a Weibull proportional hazards model. The results indicate that the distribution of age at onset of faecal shedding in Holstein-Frisian dairy cattle in infected herds is associated with the within-herd prevalence. In higher classes of apparent prevalence, cattle started to shed Map at younger age on average. In herds with an apparent prevalence = 0.2, the proportion (95% CI) of cattle with onset of faecal shedding before 2 years of age was estimated at 1% (0.5%; 2%), 4% (3%; 5%), 8% (5%; 10%) and 20% (11%; 32%), respectively. This study indicates that a considerable proportion of young stock is shedding Map, especially in high prevalence herds. Therefore, infectious young stock should be a major concern in the control of paratuberculosis
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