Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 407578
Title Influence of nutrition on feline calcium oxalate urolithiasis with emphasis on endogenous oxalate synthesis
Author(s) Dijcker, J.C.; Plantinga, E.A.; Baal, J. van; Hendriks, W.H.
Source Nutrition Research Reviews 24 (2011)1. - ISSN 0954-4224 - p. 96 - 110.
DOI https://doi.org/10.1017/S0954422410000351
Department(s) Animal Nutrition
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) alanine-glyoxylate aminotransferase - l-glyceric aciduria - urinary relative supersaturation - ammonium phosphate urolithiasis - primary hyperoxaluria type-2 - clinically normal cats - high-protein diet - stone-formers - oxalobacter-formigenes - healthy dogs
Abstract The prevalence of calcium oxalate (CaOx) uroliths detected in cats with lower urinary tract disease has shown a sharp increase over the last decades with a concomitant reciprocal decrease in the occurrence of struvite (magnesium ammonium phosphate) uroliths. CaOx stone-preventative diets are available nowadays, but seem to be marginally effective, as CaOx urolith recurrence occurs in patients fed these diets. In order to improve the preventative measures against CaOx urolithiasis, it is important to understand its aetiopathogenesis. The main research focus in CaOx formation in cats has been on the role of Ca, whereas little research effort has been directed towards the role and origin of urinary oxalates. As in man, the exogenous origin of urinary oxalates in cats is thought to be of minor importance, although the precise contribution of dietary oxalates remains unclear. The generally accepted dietary risk factors for CaOx urolithiasis in cats are discussed and a model for the biosynthetic pathways of oxalate in feline liver is provided. Alanine:glyoxylate aminotransferase 1 (AGT1) in endogenous oxalate metabolism is a liver-specific enzyme targeted in the mitochondria in cats, and allows for efficient conversion of glyoxylate to glycine when fed a carnivorous diet. The low peroxisomal activity of AGT1 in cat liver is compatible with the view that felids utilised a low-carbohydrate diet throughout evolution. Future research should focus on understanding de novo biosynthesis of oxalate in cats and their adaptation(s) in oxalate metabolism, and on dietary oxalate intake and absorption by cats.
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