Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 407729
Title Mechanical and thermal stabilities of peptide amphipile fibres
Author(s) Heuvel, M. van den; Baptist, H.G.M.; Venema, P.; Linden, E. van der; Löwik, D.W.P.M.; Hest, J.C.M. van
Source Soft Matter 7 (2011). - ISSN 1744-683X - p. 9737 - 9743.
Department(s) Physics and Physical Chemistry of Foods
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) molecular architecture - aqueous-solution - amyloid fibrils - shear-flow - nanofibers - protein - polymerization - aggregation - scaffolds - hydrogels
Abstract In this study the thermal and mechanical stabilities of self-assembled fibres of palmitoyl functionalized GANPNAAG have been examined. The thermal stability was investigated with circular dichroism, dynamic light scattering and fluorescence measurements monitoring the disassembly upon heating and reassembly upon cooling. The determination of the temperature dependence of the critical aggregation concentration allowed us to estimate the thermodynamic parameters involved in the fibre formation process. The mechanical stability of the fibres was studied using flow-induced birefringence. The peptide based self-assembled structures were found to be thermally stable up to 70 [degree]C, while being fractured by moderate shear flow.
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