Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 408207
Title Comparing the sensitivity of algal, cyanobacterial and bacterial bioassays to different groups of antibiotics
Author(s) Grinten, E. van der; Pikkemaat, M.G.; Brandhof, E.J. Van den; Stroomberg, G.J.; Kraak, M.H.S.
Source Chemosphere 80 (2010)1. - ISSN 0045-6535 - p. 1 - 6.
DOI https://doi.org/10.1016/j.chemosphere.2010.04.011
Department(s) RIKILT - R&C Diergeneesmiddelen
Publication type Refereed Article in a scientific journal
Publication year 2010
Keyword(s) tandem mass-spectrometry - environmental risk-assessment - aquatic environment - waste-water - fluoroquinolone antibiotics - antibacterial agents - antimicrobial agents - treatment plants - ecotoxicity test - vibrio-fischeri
Abstract Antibiotics may affect both primary producers and decomposers, potentially disrupting ecosystem processes. Hence, it is essential to assess the impact of antibiotics on aquatic ecosystems. The aim of the present study was therefore to evaluate the potential of a recently developed test for detecting antibiotics in animal tissue, the Nouws Antibiotic Test (NAT), as a sensitive bioassay to assess the effects of antibiotics in water. To this purpose, we determined the toxicity of sulphamethoxazole, trimethoprim, flumequine, tylosin, streptomycin, and oxytetracycline, using the NAT adapted for water exposure. The sensitivity of the NAT was compared to that of bioassays with bacteria (Microtox), cyanobacteria and green algae. In the Microtox test with Vibrio fischeri as test organism, no effects were observed for any of the test compounds. For three of the six antibiotics tested, the cyanobacteria were more vulnerable than the green algae when using photosynthetic efficiency as an endpoint. The lowest EC50 values for four out of six tested antibiotics were obtained using the NAT bacterial bioassay. The bacterial plate system responded to antibiotics at concentrations in the mu g L-1 and lower mg L-1 range and, moreover, each plate proved to be specifically sensitive to the antibiotics group it was designed for. It is concluded that the NAT bioassay adapted for water exposure is a sensitive test to determine the presence of antibiotics in water. The ability of this test to distinguish five major antibiotic groups is a very strong additional value.
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