Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 408227
Title Serum Iron Parameters, HFE C282Y Genotype, and Cognitive Performance in Older Adults: Results From the FACIT Study
Author(s) Schiepers, O.J.G.; Boxtel, M.P.J. van; Groot, R.H.M.; Jolles, J.; Kort, W.L.A.M. de; Swinkels, D.W.; Kok, F.J.; Verhoef, P.; Durga, J.
Source Journals of Gerontology. Series A: Biological Sciences & Medical Sciences 65 (2010)12. - ISSN 1079-5006 - p. 1312 - 1321.
DOI http://dx.doi.org/10.1093/gerona/glq149
Department(s) Chair Nutrition and Health over the Lifecourse
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2010
Keyword(s) transferrin-bound iron - participants aged 24-81 - restless legs syndrome - normative data - alzheimers-disease - gene-mutations - neurodegenerative disorders - hereditary hemochromatosis - parkinsons-disease - physical-activity
Abstract Although iron homeostasis is essential for brain functioning, the effects of iron levels on cognitive performance in older individuals have scarcely been investigated. In the present study, serum iron parameters and hemochromatosis (HFE) C282Y genotype were determined in 818 older individuals who participated in a 3-year randomized, placebo-controlled double-blind trial examining the effects of folic acid on carotid intima-media thickness. All participants had slightly elevated homocysteine levels and were vitamin B12 replete. Cognitive functioning was assessed at baseline and after 3 years by means of a neuropsychological test battery. At baseline, increased serum ferritin was associated with decreased sensorimotor speed, complex speed, and information-processing speed and increased serum iron was associated with decreased sensorimotor speed. Cognitive performance over 3 years was not associated with HFE C282Y genotype or iron parameters. In conclusion, serum iron parameters do not show a straightforward relationship with cognitive functioning, although elevated iron levels may decrease cognitive speed in older individuals susceptible to cognitive impairment.
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