Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 408281
Title Maternal micronutrient supplementation with zinc and beta-carotene affects morbidity and immune function of infants during the first 6 months of life
Author(s) Wieringa, F.T.; Dijkhuizen, M.A.; Muhilal, ; Meer, J.W.M. van der
Source European Journal of Clinical Nutrition 64 (2010)10. - ISSN 0954-3007 - p. 1072 - 1079.
Department(s) Human Nutrition (HNE)
Publication type Refereed Article in a scientific journal
Publication year 2010
Keyword(s) vitamin-a supplementation - placebo-controlled trial - low-birth-weight - double-blind - indonesian infants - randomized-trial - pregnant-women - mortality - children - deficiency
Abstract Background/Objectives: Micronutrient deficiencies are prevalent worldwide, and a major cause of infant death. Supplementation with multiple micronutrients during pregnancy might improve micronutrient status of the newborn, thereby reducing morbidity and death. Moreover, maternal supplementation might affect the newborn's immune development. Therefore, this study investigated the effects of maternal zinc and beta-carotene supplementation on the infant's morbidity and immune function during the first 6 months of life. Subjects/Methods: Mothers were supplemented during pregnancy with beta-carotene and/or zinc, in addition to iron and folic acid, in a randomized, double-blind controlled trial. Newborn infants (n = 136) were followed up for 6 months. Results: Infants born from mothers receiving zinc during pregnancy had significantly fewer episodes of diarrhoea than infants born from mothers not receiving zinc (0.2 and 0.4, respectively), but more episodes of cough (1.3 and 0.9 respectively) during the first 6 months. Maternal beta-carotene supplementation had no effect on infants' morbidity. Cytokine production in the newborns was affected by maternal zinc and beta-carotene supplementation, with zinc supplementation giving higher interleukin-6 production (16% higher), and beta-carotene supplementation leading to lower interferon-g production (36% lower). Conclusions: This study shows that maternal supplementation with zinc and beta-carotene affected the newborn's immune development in specific ways, but only maternal zinc supplementation significantly affected morbidity in the infants. Addition of zinc to routine iron and folic acid supplements for pregnant women could be an effective way to reduce diarrhoeal disease during the first 6 months of life, albeit at the expense of more episodes of cough. European Journal of Clinical Nutrition (2010) 64, 1072-1079; doi:10.1038/ejcn.2010.115; published online 4 August 2010
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