Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 408713
Title Guidelines for optimal design of coflow enzyme microreactors
Author(s) Kolfschoten, R.C.; Swarts, J.W.; Janssen, A.E.M.; Boom, R.M.
Source Chemical Engineering Journal 172 (2011)2-3. - ISSN 1385-8947 - p. 1072 - 1077.
Department(s) FBR Food Technology
Food Process Engineering
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) diffusion
Abstract Enzyme microreactors are used as research tools because of many advantages including low reagent consumption and the general notion that mass transfer restrictions are reduced. The use of microchannels can indeed shorten the characteristic mass transfer time but may also affect the productivity of the microreactor. To what extent mass transfer restrictions affect the reaction rate and the productivity is determined by parameters such as the enzyme properties, operating conditions, and dimensions of the microreactor. This article provides the correlations between these parameters for coflow enzyme microreactors obeying Michaelis–Menten kinetics. These correlations outline the design space based on reduced mass transfer restrictions and maximum productivity, respectively. The methodology that yields the design space provides a generic hands-on approach to optimally design coflow enzyme microreactors. We conclude that effectiveness is an important parameter for designing microreactors, but – depending on the reactor configuration – does not necessarily lead to optimized throughput. We demonstrate design windows to illustrate this effect and how to take advantage of it.
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