Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 408997
Title Effects of surplus dietary L-tryptophan on stress, immunology, behavior, and nitrogen retention in endotoxemic pigs
Author(s) Koopmans, S.J.; Staay, F.J. van der; Floc'h Le, N.; Dekker, R.A.; Diepen, J.T.M. van; Jansman, A.J.M.
Source Journal of Animal Science 90 (2012)1. - ISSN 0021-8812 - p. 241 - 251.
DOI http://dx.doi.org/10.2527/jas.2010-3372
Department(s) Adaptation Physiology
Livestock Research
LR - Backoffice
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) chronic lung inflammation - acute-phase proteins - c-reactive protein - plasma-cortisol - indoleamine 2,3-dioxygenase - metabolism - lipopolysaccharide - degradation - catabolism - tolerance
Abstract The possible beneficial effects of surplus dietary Trp (+ 5 g Trp/kg diet) were investigated on factors related to stress, immunology, behavior, and N retention in post-weaning piglets (approximately 15 kg BW) challenged for 10 d with intravenous bacterial lipopolysaccharide (LPS; from Escherichia coli). Two diets fed restrictively (732 kJ NE/kg BW0.75/d) were compared: 1) basal diet (B; apparent ileal digestible Trp = 1.9 g/kg; a recommended level of Trp to warrant near-optimal growth in non-endotoxemic piglets) and 2) Trp enriched B (+ 5 g free L-Trp/kg) with 8 individually housed piglets per diet. Pooled salivary cortisol, but not plasma cortisol sampled at sacrifice, showed a tendency (P = 0.07) towards reduced concentrations in the Trp group (1.1 vs. 1.4 ng/mL; pooled SE = 0.1 ng/mL). Plasma C-reactive protein was reduced (P = 0.04) in the Trp group (0.9 vs. 5.0 mg/L; pooled SE = 1.3 mg/L), but haptoglobin, IL-6, tumor necrosis factor alpha, and LPS-induced fever were similar between the 2 dietary treatments. Physical activity related to approaching a human showed a tendency (P = 0.08) towards increased latency time in the Trp group (101 vs. 60 s; pooled SE = 16 s) but the times spent on standing, sitting, and lying were similar between dietary treatments. The ADFI, ADG (346 vs. 302 g/d; pooled SE = 14 g/d; P = 0.11), body N retention (11.6 vs. 11.0 g/d; pooled SE = 0.2 g/d; P = 0.18), and G:F (0.55 vs. 0.49; pooled SE = 0.03; P = 0.17) were not different between the Trp and B fed groups. In conclusion, surplus dietary Trp has limited impact on stress, immunology, behavior, and N retention in a pig model of systemic endotoxemia.
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