Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 409094
Title Lymphatic vascular morphogenesis in development, physiology, and disease
Author(s) Schulte-Merker, S.; Sabine, A.; Petrova, T.V.
Source Journal of Cell Biology 193 (2011)4. - ISSN 0021-9525 - p. 607 - 618.
Department(s) Experimental Zoology
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) lymphedema-distichiasis syndrome - endothelial-cell fate - growth-factor-c - vessel development - transcription factor - coup-tfii - vegf-c - pulmonary lymphangioleiomyomatosis - embryonic lymphangiogenesis - hereditary lymphedema
Abstract The lymphatic vasculature constitutes a highly specialized part of the vascular system that is essential for the maintenance of interstitial fluid balance, uptake of dietary fat, and immune response. Recently, there has been an increased awareness of the importance of lymphatic vessels in many common pathological conditions, such as tumor cell dissemination and chronic inflammation. Studies of embryonic development and genetically engineered animal models coupled with the discovery of mutations underlying human lymphedema syndromes have contributed to our understanding of mechanisms regulating normal and pathological lymphatic morphogenesis. It is now crucial to use this knowledge for the development of novel therapies for human diseases
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