Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 409272
Title Modeling lipid accumulation in oleaginous fungi in chemostatcultures. II: Validation of the chemostat model using yeast culturedata from literature
Author(s) Meeuwse, P.; Tramper, J.; Rinzema, A.
Source Bioprocess and Biosystems Engineering 34 (2011)8. - ISSN 1615-7591 - p. 951 - 961.
Department(s) Bioprocess Engineering
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) stage continuous-culture - gamma-linolenic acid - rhodotorula-glutinis - apiotrichum-curvatum - candida-curvata - growth-rate - oxygen - batch
Abstract A model that predicts cell growth, lipid accumulation and substrate consumption of oleaginous fungi in chemostat cultures (Meeuwse et al. in Bioproc Biosyst Eng. doi: 10.1007/s00449-011-0545-8 , 2011) was validated using 12 published data sets for chemostat cultures of oleaginous yeasts and one published data set for a poly-hydroxyalkanoate accumulating bacterial species. The model could describe all data sets well with only minor modifications that do not affect the key assumptions, i.e. (1) oleaginous yeasts and fungi give the highest priority to C-source utilization for maintenance, second priority to growth and third priority to lipid accumulation, and (2) oleaginous yeasts and fungi have a growth rate independent maximum specific lipid production rate. The analysis of all data showed that the maximum specific lipid production rate is in most cases very close to the specific production rate of membrane and other functional lipids for cells growing at their maximum specific growth rate. The limiting factor suggested by Ykema et al. (in Biotechnol Bioeng 34:1268-1276, 1989), i.e. the maximum glucose uptake rate, did not give good predictions of the maximum lipid production rate
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