Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 410016
Title Synthesis of LewisX epitopes on proteins in plants
Author(s) Rouwendal, G.J.A.; Bosch, H.J.; Florack, D.E.A.
Source Octrooinummer: WO2007145523, verleend: 2007-12-21.
Department(s) PRI Bioscience
PRI BIOS Applied Metabolic Systems
Publication type Patent
Publication year 2007
Abstract The invention comprises a method to produce a Lewis X epitope on N-linked glycans on glycoproteins in a plant, plant part or plant cells, comprising expression of a nucleotide sequence encoding a galactosyltransferase, which catalyzes the addition of galactose in ßl,4-linkage to N-linked glycans, and expression of a nucleotide sequence encoding a fucosy transferase, which catalyzes the addition of fucose in al,3-linkage to the N-acetylglucosamine of GalBl-4GlcNAc structures on N-linked glycans, and expression of one or more nucleotide sequences encoding one or more glycoproteins, which are able to be provided with an N-linked glycan, in said plant, plant part or plant cell. The fucosyltransferase comprises preferably the catalyticaal active domain of FUT9 from T. nigrovi
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