Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 410019
Title Alg3 Mutant
Author(s) Bosch, H.J.; Krol, S. van der; Henquet, M.G.L.; Florack, D.E.A.
Source Octrooinummer: WO2008143513, verleend: 2008-11-27, Wageningen UR.
Department(s) PRI BIOS Applied Metabolic Systems
Laboratory of Plant Physiology
PRI Bioscience
Publication type Patent
Publication year 2008
Abstract The present invention relates to a method to produce proteins reduced in high mannose type glycans in a plant or plant cell by partially inhibiting the expression of the Alg3 gene in said plant or plant cell. Said partial inhibition can be provided for by inserting the Alg3 mutant gene from Arabidopsis as derived from the plant line Salk_040296c or by partially inhibiting the endogenous Alg3 gene by providing the plant or plant cell either with an antisense expression, a sense co-suppressing or with an RNA inhibition genetic construct. Optionally also tissue-specific expression of said inhibiting constructs can yield partial inhibition in a plant.
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