Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 410124
Title Modelling the dynamics of viral suppressors of RNA silencing
Author(s) Groenenboom, M.A.C.
Source Journal of the Royal Society, Interface 9 (2012)68. - ISSN 1742-5689 - p. 436 - 447.
DOI http://dx.doi.org/10.1098/rsif.2011.0361
Department(s) Biometris (WU MAT)
PE&RC
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) small interfering rnas - virus - argonaute1 - risc - degradation - biogenesis - proteins - cleavage - defense - p0
Abstract Virus infection in plants is limited by RNA silencing. In turn, viruses can counter RNA silencing with silencing suppressors. Viral suppressors of RNA silencing have been shown to play a role in symptom development in plants. We here study four different strategies employed by silencing suppressors: small interfering RNA (siRNA) binding, double-strand RNA (dsRNA) binding and degrading or inactivating Argonaute. We study the effect of the suppressors on viral accumulation within the cell as well as its spread on a tissue with mathematical and computational models. We find that suppressors which target Argonaute are very effective in a single cell, but that targeting dsRNA or siRNA is much more effective at the tissue level. Although targeting Argonaute can be beneficial for viral spread, it can also cause hindrance in some cases owing to raised levels of siRNAs that can spread to other cells.
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