Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 410441
Title Porous microcapsule formation with microsieve emulsification
Author(s) Wagdare, N.A.; Marcelis, A.T.M.; Boom, R.M.; Rijn, C.J.M. van
Source Journal of Colloid and Interface Science 355 (2011)2. - ISSN 0021-9797 - p. 453 - 457.
Department(s) Laboratory for Organic Chemistry
Food Process Engineering
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) internal phase-separation - premix membrane emulsification - polymer shell microcapsules - emulsion droplets - delivery - polylactide - particles - release - size - colloidosomes
Abstract A simple route is presented to prepare core–shell Eudragit microcapsules through a solvent extraction method with the use of microsieve emulsification. Droplets from a solution of Eudragit FS 30D (a commercial copolymer of poly(methyl acrylate-co-methyl methacrylate-co-methacrylic acid) 7:3:1) and hexadecane in dichloromethane are dispersed into water, using a micro-engineered membrane with well-defined pores, in a cross-flow setting. The dichloromethane is extracted from the droplets, which induces demixing in the droplets, leading to a hexadecane-rich core, and an Eudragit-rich shell. The obtained microcapsules have a narrow size distribution due to the microsieve emulsification process. The capsules have a porous shell as shown by SEM and AFM measurements. Their porosity and pore size is dependent on the ratios of Eudragit and hexadecane in the dispersed phase. At pH 7.1 and above Eudragit (FS 30D) dissolves in water; this pH change is used to release the contents of the microcapsule
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