Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 411241
Title The (epi)genetics of human synovial sarcoma
Author(s) Bruijn, D.R.H. de; Nap, J.P.H.; Kessel, A.G.
Source Genes Chromosomes and Cancer 46 (2007)2. - ISSN 1045-2257 - p. 107 - 117.
Department(s) PRI BIOS Applied Bioinformatics
Publication type Refereed Article in a scientific journal
Publication year 2007
Keyword(s) polymerase-chain-reaction - ssx fusion transcripts - chromatin remodeling complexes - proto-oncoprotein syt - nuclear receptor coactivator - paraffin-embedded tissues - in-situ hybridization - leucine-zipper motif - high-dose ifosfamide - prognostic-factors
Abstract Human synovial sarcomas are aggressive soft tissue tumors with relatively high rates of recurrences and metastases. They display a variable response to common treatment protocols such as radiation and chemotherapy. For the development of novel diagnostic, prognostic, and therapeutic approaches, detailed information on the molecular mechanisms underlying the development of these tumors is of imperative importance. Fusion of the SS18 and (one of the) SSX genes is a molecular hallmark of human synovial sarcomas. The SS18 and SSX genes encode nuclear proteins that exhibit opposite transcription regulatory activities, likely through epigenetic mechanisms. The SS18 protein functions as a transcriptional coactivator and interacts directly with members of the epigenetic chromatin remodeling and modification machineries. In contrast, the SSX proteins function as transcriptional corepressors and are associated with several Polycomb group proteins. Since the domains involved in these apparently opposite transcription regulatory activities are retained in the SS18-SSX fusion proteins, we hypothesize that these fusion proteins function as "activator-repressors" of transcription. The implications of this model for human synovial sarcoma development and future treatment are discussed.
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