Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 413170
Title Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal endpoints: a brief discussion of concepts
Author(s) Ashauer, R.; Agatz, A.; Albert, C.; Ducrot, V.; Galic, N.G.; Hendriks, J.; Jager, T.; Kretschmann, A.; O'Connor, I.; Rubach, M.N.; Nyman, M.; Schmitt, W.; Stadnicka, J.; Brink, P.J. van den
Source Environmental Toxicology and Chemistry 30 (2011)11. - ISSN 0730-7268 - p. 2519 - 2524.
DOI https://doi.org/10.1002/etc.639
Department(s) Aquatic Ecology and Water Quality Management
CWC - Environmental Risk Assessment
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) time-varying concentrations - biology-based approach - gammarus-pulex - daphnia-magna - population-dynamics - organic-chemicals - mixture toxicity - pulsed exposure - binary-mixtures - hyalella-azteca
Abstract We report on the advantages and problems of using toxicokinetic-toxicodynamic (TKTD) models for the analysis, understanding, and simulation of sublethal effects. Only a few toxicodynamic approaches for sublethal effects are available. These differ in their effect mechanism and emphasis on linkages between endpoints. We discuss how the distinction between quantal and graded endpoints and the type of linkage between endpoints can guide model design and selection. Strengths and limitations of two main approaches and possible ways forward are outlined
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