Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 41357
Title A mixture model approach to the mapping of quantitative trait loci in complex populations with an application to multiple cattle families.
Author(s) Jansen, R.C.; Johnson, D.L.; Arendonk, J.A.M. van
Source Genetics 148 (1998). - ISSN 0016-6731 - p. 391 - 399.
Department(s) Animal Breeding and Genetics
Centrum voor Plantenveredelings- en Reproduktieonderzoek
Publication type Refereed Article in a scientific journal
Publication year 1998
Abstract A mixture model approach is presented for the mapping of one or more quantitative trait loci (QTLs) in complex populations. In order to exploit the full power of complete linkage maps the simultaneous likelihood of phenotype and a multilocus (all markers and putative QTLs) genotype is computed. Maximum likelihood estimation in our mixture models is implemented via an Expectation-Maximization algorithm: exact, stochastic or Monte Carlo EM by using a simple and flexible Gibbs sampler. Parameters include allele frequencies of markers and QTLs, discrete or normal effects of biallelic or multiallelic QTLs, and homogeneous or heterogeneous residual variances. As an illustration a dairy cattle data set consisting of twenty half-sib families has been reanalyzed. We discuss the potential which our and other approaches have for realistic multiple-QTL analyses in complex populations.
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