Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 413777
Title Evaluation of research activities and research needs to increase the impact and applicability of alternative testing strategies in risk assessment practice
Author(s) Punt, A.; Schiffelers, M.J.W.A.; Horbach, J.; Sandt, J.J.M. van de; Groothuis, G.M.M.; Rietjens, I.; Blaauboer, B.J.
Source Regulatory Toxicology and Pharmacology 61 (2011)1. - ISSN 0273-2300 - p. 105 - 114.
DOI http://dx.doi.org/10.1016/j.yrtph.2011.06.007
Department(s) Sub-department of Toxicology
WU Agrotechnology and Food SciencesDepartment of Agrotechnology and Food Sciences
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) vitro toxicity data - biokinetic pbbk model - eu reach legislation - stem-cell test - in-vitro - pharmacokinetic models - estragole bioactivation - developmental toxicity - partition-coefficients - reproductive toxicity
Abstract The present paper aims at identifying strategies to increase the impact and applicability of alternative testing strategies in risk assessment. To this end, a quantitative and qualitative literature evaluation was performed on (a) current research efforts in the development of in vitro methods aiming for alternatives to animal testing, (b) the possibilities and limitations of in vitro methods for regulatory purposes and (c) the potential of physiologically-based kinetic (PBK) modeling to improve the impact and applicability of in vitro methods in risk assessment practice. Overall, the evaluation showed that the focus of state-of-the-art research activities does not seem to be optimally directed at developing in vitro alternatives for those endpoints that are most animal-demanding, such as reproductive and developmental toxicity, and carcinogenicity. A key limitation in the application of in vitro alternatives to such systemic endpoints is that in vitro methods do not provide so-called points of departure, necessary for regulators to set safe exposure limits. PBK-modeling could contribute to overcoming this limitation by providing a method that allows extrapolation of in vitro concentration-response curves to in vivo dose-response curves. However, more proofs of principle are required.
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