Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 414564
Title Levels of Genotoxic and Carcinogenic Compounds in Plant food Supplements and Associated Risk Assessment
Author(s) Berg, S.J.P.L. van den; Restani, P.; Boersma, M.G.; Delmulle, L.; Rietjens, I.
Source Food and Nutrition Sciences 2 (2011). - ISSN 2157-944X - p. 989 - 1010.
DOI https://doi.org/10.4236/fns.2011.29134
Department(s) Sub-department of Toxicology
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2011
Abstract The present study describes the selection, analysis and risk assessment of genotoxic and carcinogenic compounds of botanicals and botanical preparations which can be found in plant food supplements (PFS). First an inventory was made of botanical compounds that are of possible concern for human health because of their genotoxic and/or car- cinogenic properties. In total, 30 botanical compounds were selected and subsequently judged for their actual genotoxic and/or carcinogenic potential. Among the 30 compounds considered, 18 compounds were judged to be both genotoxic and carcinogenic. Interestingly, the majority of these compounds belong to the group of alkenylbenzenes or unsaturated pyrrolizidine alkaloids. Subsequently, based on available carcinogenicity data and estimated daily human exposure that was determined focusing on the intake from PFS, the Margin of Exposure (MOE) was calculated for the alkenylbenzenes estragole, methyleugenol, safrole and ß-asarone. Calculating the MOEs for intake estimates of these alkenylbenzenes from PFS resulted in MOE values that were generally lower than 10,000 and often lower than 100. In some cases the MOE was even below 10 meaning that the estimated daily intake is in the range of dose levels causing malignant tumors in experimental animals. This result indicates that the use of PFS containing the genotoxic carcino-gens estragole, methyleugenol, safrole or ß-asarone might raise a potential concern for human health and would be of high priority for risk management
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