Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 414674
Title Tutorial on physiologically based kinetic modeling in molecular nutrition and food research
Author(s) Rietjens, I.; Louisse, J.; Punt, A.
Source Molecular Nutrition & Food Research 55 (2011)6. - ISSN 1613-4125 - p. 941 - 956.
DOI https://doi.org/10.1002/mnfr.201000655
Department(s) Sub-department of Toxicology
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) naturally-occurring alkenylbenzenes - post-labeling analysis - vitro toxicity data - in-vitro - risk-assessment - dna-adducts - pharmacokinetic models - partition-coefficients - pbpk model - pharmacokinetic/pharmacodynamic model
Abstract Studies in the field of molecular nutrition and food research often aim at identifying effects of bioactive ingredients on living organisms. When data from human studies are difficult to obtain, effects are often studied in relevant animal or cellular in vitro models. This poses the need for adequate extrapolation from the in vitro to the in vivo situation, from high-dose levels to realistic low-dose levels and from experimental animals to humans. Furthermore, effects of genetic polymorphisms or lifestyle factors may have to be taken into account. Physiologically based kinetic (PBK) modeling provides a means to support these kinds of extrapolations. The present paper illustrates the basic concepts of PBK modeling. PBK modeling includes six steps: (i) definition of the conceptual model, (ii) translation into a mathematical model, (iii) defining parameter values, (iv) solving the equations, (v) evaluation of model performance and (vi) making predictions. The paper provides an overview of these basic steps and presents examples to illustrate how PBK modeling can be applied. This reveals that PBK modeling provides an important tool in the field of the 3Rs aiming at Replacement, Reduction and Refinement of animal studies and may also be a useful tool for risk assessment
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