Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 414757
Title The need and Potential of Biosensors to Detect Dioxins and Dioxin-Like Polychlorinated Biphenyls along the Milk, Eggs and Meat Food Chain
Author(s) Chobtang, J.; Boer, I.J.M. de; Hoogenboom, L.A.P.; Haasnoot, W.; Kijlstra, A.; Meerburg, B.G.
Source Sensors 11 (2011)12. - ISSN 1424-8220 - p. 11692 - 11716.
DOI http://dx.doi.org/10.3390/s111211692
Department(s) Animal Production Systems
Rikilt B&T Toxicologie en Effectanalyse
RIKILT - R&C Diergeneesmiddelen
Livestock Research
LR - Backoffice
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) aryl-hydrocarbon receptor - dibenzo-p-dioxins - toxic equivalency factors - solid-phase extraction - home-produced eggs - free-range eggs - calux-bioassay - dr-calux(r) bioassay - chemical contamination - microbial biosensors
Abstract Dioxins and dioxin-like polychlorinated biphenyls (DL-PCBs) are hazardous toxic, ubiquitous and persistent chemical compounds, which can enter the food chain and accumulate up to higher trophic levels. Their determination requires sophisticated methods, expensive facilities and instruments, well-trained personnel and expensive chemical reagents. Ideally, real-time monitoring using rapid detection methods should be applied to detect possible contamination along the food chain in order to prevent human exposure. Sensor technology may be promising in this respect. This review gives the state of the art for detecting possible contamination with dioxins and DL-PCBs along the food chain of animal-source foods. The main detection methods applied (i.e., high resolution gas-chromatography combined with high resolution mass-spectrometry (HRGC/HRMS) and the chemical activated luciferase gene expression method (CALUX bioassay)), each have their limitations. Biosensors for detecting dioxins and related compounds, although still under development, show potential to overcome these limitations. Immunosensors and biomimetic-based biosensors potentially offer increased selectivity and sensitivity for dioxin and DL-PCB detection, while whole cell-based biosensors present interpretable biological results. The main shortcoming of current biosensors, however, is their detection level: this may be insufficient as limits for dioxins and DL-PCBs for food and feedstuffs are in pg per gram level. In addition, these contaminants are normally present in fat, a difficult matrix for biosensor detection. Therefore, simple and efficient extraction and clean-up procedures are required which may enable biosensors to detect dioxins and DL-PCBs contamination along the food chain.
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