Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

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Record number 415034
Title Outstanding: the dispensable chromosomes of Mycosphaerella graminicola
Author(s) M'Barek, S. Ben; Lee, T.A.J. van der; Wittenberg, A.H.J.; Ware, S.B.; Maliepaard, C.A.; Crane, C.F.; Dhillon, B.; Goodwin, S.B.; Schouten, H.J.; Kema, G.H.J.
Source In: Plenary Session Abstracts. 25th Fungal Genetics Conference, Asilomar, USA, 17-22 March 2009. - Kansas City, USA : FGSC - p. 82 (#102) - 82 (#102).
Event Kansas City, USA : FGSC 25th Fungal Genetics Conference, Asilomar, USA, 2009-03-17/2009-03-22
Department(s) Biointeracties and Plant Health
PRI BIOINT Moleculair Phytopathology
PRI Biodiversity and Breeding
Laboratory of Plant Breeding
WUR Plant Breeding
Publication type Abstract in scientific journal or proceedings
Publication year 2009
Abstract Analysis of two genetic linkage maps of the wheat pathogen Mycosphaerella graminicola identified dispensable chromosomes that were present in both parents but absent in 15-20 % of the progeny. These Copy number Polymorphisms (CNPs) were confirmed with a Comparative Genomic Hybridization whole-genome array based on the finished genome of M. graminicola ( Chromosomes 14- 21 were frequently absent among isolates, without visible effect on viability or virulence, whereas chromosomes 1-13 were invariably present. Genetic analyses showed that CNPs arises during meiosis, usually from nondisjunction at anaphase II. Overall, M. graminicola has the highest number of dispensable chromosomes reported. Varying from 0.41 to 0.77 Mbp, they comprise 38% of the chromosome number and 11.6% of the genome. The dispensable chromosomes are smaller and have significantly lower gene densities. Most of their genes are duplicated on the essential chromosomes and show a different codon usage. Dispensable chromosomes also contained a higher density of transposons, pseudogenes, and unclassified genes, which could encode novel proteins. Moreover, the dispensable chromosomes show extremely low synteny with other Dothideomycete genomes. We hypothesize that the dispensable chromosomes of M. graminicola are adaptive in some yet unknown way
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