Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 416778
Title Dynamics of shiga-toxin producing Escherichia coli (STEC) and their virulence factors in cattle
Author(s) Dopfer, D.D.V.; Geue, L.; Schares, S.; Mintel, B.; Hoffmann, B.; Fischer, E.A.J.
Source Preventive Veterinary Medicine 103 (2012)1. - ISSN 0167-5877 - p. 22 - 30.
Department(s) CVI - Division Virology
CVI Diagnostics and Crisis
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) hemolytic uremic syndrome - coli o157-h7 - feedlot cattle - epithelial-cells - multiplex pcr - dna-sequence - strains - plasmid - o157h7 - farms
Abstract Starting at birth, twenty Holstein calves were housed individually, in groups of five and finally in one large freestall while fecal samples were collected weekly for 25 weeks. From each sample, twenty isolates of Escherichia coli were screened for 6 virulence markers including shiga-toxin 1, 2, intimin, enterohemolysin, the fimbrial antigen efa1 and the adhesin saa. Dynamic models of transmission of E. coli were used to model the transmission of different virulotypes between calves and the loss of the same virulotypes from the calves. It was found that, once E. coli encoding shiga-toxins in combination with enterohemolysin were transmitted and established in a calf, they tended to be eliminated less efficiently compared to E. coli without this combination of virulence markers. It was concluded that the presence of certain combinations of virulence markers coincided with persistence of E. coli in the bovine gastrointestinal tract. In addition, the combinations of stx with either eae or ehxA in E. coli have a greater impact on the loss rates than on the transmission rates.
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