Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 417079
Title The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus
Author(s) Kootte, R.S.; Vrieze, A.; Holleman, F.; Zoetendal, E.G.; Vos, W.M. de; Groen, A.K.; Hoekstra, J.B.; Nieuwdorp, M.
Source Diabetes, Obesity & Metabolism 14 (2012)2. - ISSN 1462-8902 - p. 112 - 120.
Department(s) Microbiological Laboratory
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) diet-induced obesity - human intestinal microbiota - chain fatty-acids - lactobacillus-casei - bile-acids - in-vivo - gastrointestinal-tract - insulin-resistance - metagenomic analysis - bacterial community
Abstract Obesity and type 2 diabetes mellitus (T2DM) are attributed to a combination of genetic susceptibility and lifestyle factors. Their increasing prevalence necessitates further studies on modifiable causative factors and novel treatment options. The gut microbiota has emerged as an important contributor to the obesity-and T2DM-epidemic proposed to act by increasing energy harvest from the diet. Although obesity is associated with substantial changes in the composition and metabolic function of the gut microbiota, the pathophysiological processes remain only partly understood. In this review we will describe the development of the adult human microbiome and discuss how the composition of the gut microbiota changes in response to modulating factors. The influence of short-chain fatty acids, bile acids, prebiotics, probiotics, antibiotics and microbial transplantation is discussed from studies using animal and human models. Ultimately, we aim to translate these findings into therapeutic pathways for obesity and T2DM in humans
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