Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 417408
Title Population dynamics of the liver fluke, Fasciolia hepatica: the effect of time and spatial separation on the genetic diversity of fluke populations in the Netherlands.
Author(s) Walker, S.M.; Johnston, C.; Hoey, E.M.; Fairweather, I.; Borgsteede, F.H.M.; Gaasenbeek, C.P.H.; Prodohl, P.A.; Trudgett, A.
Source Parasitology 138 (2011). - ISSN 0031-1820 - p. 215 - 223.
DOI http://dx.doi.org/10.1017/S0031182010001149
Department(s) CVI - Divisie Bacteriologie en TSE's
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) beta-tubulin - haemonchus-contortus - drug-resistance - life-cycle - triclabendazole - sheep - cattle - ages
Abstract An evaluation of the genetic diversity within Fasciola hepatica (liver fluke) may provide an insight into its potential to respond to environmental changes, such as anthelmintic use or climate change. In this study, we determined the mitochondrial DNA haplotypes of >400 flukes from 29 individual cattle, from 2 farms in the Netherlands, as an exemplar of fasciolosis in a European context. Analysis of this dataset has provided us with a measure of the genetic variation within infrapopulations (individual hosts) and the diversity between infrapopulations within a herd of cattle. Temporal sampling from one farm allowed for the measurement of the stability of genetic variation at a single location, whilst the comparison between the two farms provided information on the variation in relation to distance and previous anthelmintic regimes. We showed that the liver fluke population in this region is predominantly linked to 2 distinct clades. Individual infrapopulations contain a leptokurtic distribution of genetically diverse flukes. The haplotypes present on a farm have been shown to change significantly over a relatively short time-period
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