Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 418040
Title Brassinosteroids inhibit pathogen-associated molecular pattern–triggered immune signaling independent of the receptor kinase BAK1.
Author(s) Albrecht, C.; Boutrot, F.; Segonzac, C.; Schwessinger, B.; Gimenez-Ibanez, S.; Rathjen, J.P.; Chinchilla, D.; Vries, S.C. de; Zipfel, C.
Source Proceedings of the National Academy of Sciences of the United States of America 109 (2012)1. - ISSN 0027-8424 - p. 303 - 308.
DOI http://dx.doi.org/10.1073/pnas.1109921108
Department(s) Biochemistry
EPS-1
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) plant innate immunity - disease resistance - gene-expression - protein complex - arabidopsis - growth - pathways - fls2 - responses - acid
Abstract Plants and animals use innate immunity as a first defense against pathogens, a costly yet necessary tradeoff between growth and immunity. In Arabidopsis, the regulatory leucine-rich repeat receptor-like kinase (LRR-RLK) BAK1 combines with the LRR-RLKs FLS2 and EFR in pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and the LRR-RLK BRI1 in brassinosteroid (BR)-mediated growth. Therefore, a potential tradeoff between these pathways mediated by BAK1 is often postulated. Here, we show a unidirectional inhibition of FLS2-mediated immune signaling by BR perception. Unexpectedly, this effect occurred downstream or independently of complex formation with BAK1 and associated downstream phosphorylation. Thus, BAK1 is not rate-limiting in these pathways. BRs also inhibited signaling triggered by the BAK1-independent recognition of the fungal PAMP chitin. Our results suggest a general mechanism operative in plants in which BR-mediated growth directly antagonizes innate immune signaling.
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