Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 418129
Title First isolation of Hepatitis E virus genotype 4 in Europe through swine surveillance in the Netherlands and Belgium.
Author(s) Honing-Hakze, R.W. van der; Coillie, E. Van; Antonis, A.F.G.; Poel, W.H.M. van der
Source PLoS One 6 (2011)8. - ISSN 1932-6203 - 6 p.
DOI http://dx.doi.org/10.1371/journal.pone.0022673
Department(s) CVI Virology
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) cross-species infection - united-states - rt-pcr - prevalence - hev - epidemiology - transmission - antibodies - sequences - humans
Abstract Hepatitis E virus (HEV) genotypes 3 and 4 are a cause of human hepatitis and swine are considered the main reservoir. To study the HEV prevalence and characterize circulating HEV strains, fecal samples from swine in the Netherlands and Belgium were tested by RT-PCR. HEV prevalence in swine was 7–15%. The Dutch strains were characterized as genotype 3, subgroups 3a, 3c and 3f, closely related to sequences found in humans and swine earlier. The HEV strains found in Belgium belonged to genotypes 3f and 4b. The HEV genotype 4 strain was the first ever reported in swine in Europe and an experimental infection in pigs was performed to isolate the virus. The genotype 4 strain readily infected piglets and caused fever and virus shedding. Since HEV4 infections have been reported to run a more severe clinical course in humans this observation may have public health implications
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