Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 418150
Title FinTRIMs, fish virus-inducible proteins with E3 ubiquitin ligase activity
Author(s) Aa, L.M. van der; Jouneau, L.; Laplantine, E.; Bouchez, O.; Verburg-van Kemenade, B.M.L.; Boudinot, P.
Source Developmental and Comparative Immunology 36 (2012)2. - ISSN 0145-305X - p. 433 - 441.
Department(s) Cell Biology and Immunology
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) antiviral defense - retroviral restriction - polyubiquitin chains - positive selection - rainbow-trout - trim proteins - e2 enzymes - family - motif - expression
Abstract TRIM proteins have recently emerged as novel players in antiviral defense. TRIM proteins contain a tri-partite motif, composed of a RING zinc finger, one or two B-boxes and a coiled-coil domain. Many members of this large protein family of E3 ubiquitin ligases catalyze the attachment of ubiquitin to a substrate protein, an activity dependent on the RING domain. We earlier made a full description of the TRIM gene family in zebrafish and pufferfish and identified three multigene TRIM subsets, a feature unique to fish. To determine their biological role, we further characterized members of the finTRIM subset. FinTRIM gene expression was studied during development and in multiple tissues in adult rainbow trout. Upregulation of a large number of finTRIM upon viral stimulation suggests they are involved in antiviral immunity. We also demonstrate that two finTRIM members display E3 ubiquitin ligase activity, indicating that finTRIMs could regulate antiviral signaling through ubiquitination
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