Staff Publications

Staff Publications

  • external user (warningwarning)
  • Log in as
  • language uk
  • About

    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 418153
Title Adrenergic regulation of the innate immune response in common carp (Cyprinus carpio L.)
Author(s) Chadzinska, M.K.; Tertil, E.; Kepka, M.; Hermsen, G.J.; Scheer, M.H.; Verburg-van Kemenade, B.M.L.
Source Developmental and Comparative Immunology 36 (2012)2. - ISSN 0145-305X - p. 306 - 316.
DOI http://dx.doi.org/10.1016/j.dci.2011.04.010
Department(s) Cell Biology and Immunology
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) trout oncorhynchus-mykiss - necrosis-factor-alpha - rainbow-trout - beta-adrenoceptors - in-vitro - beta(2)-adrenergic receptor - neutrophilic granulocytes - interleukin-10 production - corticosteroid receptors - catecholamine secretion
Abstract Catecholamines exert their physiological actions through a and ß adrenergic receptors (ARs). As ARs are not exclusively expressed on neuroendocrine cells, but also on leukocytes, they may facilitate neuroendocrine modulation of immune responses. We sequenced the ß2a-AR in common carp, and studied its expression profile and involvement in the regulation of teleost innate immune responses. ß2a-AR messenger RNA was found to be constitutively expressed in brain areas, especially in the preoptic nucleus (NPO, homologous to the mammalian hypothalamus), and in immune organs. During the active phase of an in vivo inflammatory response, induced by i.p. zymosan treatment, ß2a-AR gene expression was up-regulated in the peritoneal leukocytes. Additionally, adrenaline in vitro reduced the synthesis of oxygen radical species and nitric oxide, while it enhanced arginase activity in fish phagocytes. Furthermore, in vitro adrenaline administration inhibited expression of pro-inflammatory cytokines, chemokines and their receptors. It is therefore hypothesized that adrenaline will down-regulate phagocyte skewing toward classical/innate polarization.
Comments
There are no comments yet. You can post the first one!
Post a comment
 
Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.