Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 418182
Title The alloherpesviral counterparts of interleukin 10 in European eel and common carp.
Author(s) Beurden, S.J. van; Forlenza, M.; Westphal, A.H.; Wiegertjes, G.F.; Haenen, O.L.M.; Engelsma, M.Y.
Source Fish and Shellfish Immunology 31 (2011)6. - ISSN 1050-4648 - p. 1211 - 1217.
DOI http://dx.doi.org/10.1016/j.fsi.2011.08.004
Department(s) CVI Bacteriology and Epidemiology
Cell Biology and Immunology
Biochemistry
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) herpesviral hematopoietic necrosis - dicentrarchus-labrax l. - crystal-structure - expression analysis - immune evasion - cellular interleukin-10 - viral interleukin-10 - anguilla-anguilla - interferon-gamma - koi herpesvirus
Abstract Viral interleukin 10 (IL-10) like open reading frames have been identified in several pox- and herpesviruses, including the fish herpesviruses Anguillid herpesvirus 1 (AngHV-1) and Cyprinid herpesvirus 3 (CyHV-3). European eel (Anguilla anguilla) IL-10 was sequenced, in order to compare European eel and common carp (Cyprinus carpio) IL-10 with their alloherpesviral counterparts. Homology between the virus and host IL-10 amino acid sequences is low, which is confirmed by phylogenetic analysis. However, the three dimensional structures of the fish and alloherpesviral IL-10 proteins as predicted by modeling are highly similar to human IL-10. Closely related AngHV-1 and CyHV-3 are expected to have obtained their viral IL-10 genes independently in the course of coexistence with their respective hosts. The presence and structural conservation of these alloherpesviral IL-10 genes suggest that they might play an important role in the evolution of pathogenesis
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