Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 418281
Title Pro-inflammatory functions of carp CXCL8-like and CXCb chemokines
Author(s) Aa, L.M. van der; Chadzinska, M.K.; Golbach, L.A.; Ribeiro, C.M.S.; Verburg-van Kemenade, B.M.L.
Source Developmental and Comparative Immunology 36 (2012)4. - ISSN 0145-305X - p. 741 - 750.
Department(s) Cell Biology and Immunology
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) trout oncorhynchus-mykiss - neutrophil chemotactic factor - interleukin-8 receptors - expression analysis - edwardsiella-ictaluri - molecular evolution - sequence-analysis - gene-expression - gro-alpha - tnf-alpha
Abstract Numerous CXC chemokines have been identified in fish, however, their role in inflammation is not well established. Here, CXC chemokines of the CXCL8-like (CXCa_L1 and CXCL8_L2) and CXCL9/10/11-like (CXCb) subset were investigated in carp. Recombinant CXCa_L1, CXCL8_L2 and CXCb all stimulated chemotaxis of macrophages and granulocytes in vitro. CXCb also attracted lymphocytes. Distinct effects on phagocyte activation were observed: the CXCL8-like chemokines increase respiratory burst activity, but not nitrite production. The three chemokines differentially induced a moderate increase in IL-1ß, CXCa_L1 and CXCL8_L2 gene expression. Intracellular calcium mobilization in granulocytes upon CXCa_L1 stimulation implies signal transduction through G-protein coupled CXC receptors. Notably, upon intraperitoneal administration, carp CXCL8-like chemokines strongly induced in vivo leukocyte recruitment, including neutrophils and monocytes/macrophages, in contrast to CXCb, for which the number of recruited leukocytes was low. The results indicate functional homology for carp CXCL8-like and CXCb chemokines with mammalian CXCL8 and CXCL9-11, respectively. --------------------------------------------------------------------------------
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