Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 418394
Title Effect of a+ -thalassaemia on episodes of fever due to malaria and other causes: a communitybased cohort study in Tanzania
Author(s) Veenemans, J.; Jansen, E.J.S.; Baidjoe, A.Y.; Mbugi, E.V.; Demir, A.Y.; Kraaijenhagen, R.J.; Savelkoul, H.F.J.; Verhoef, H.
Source Malaria Journal 10 (2011). - ISSN 1475-2875 - 10 p.
Department(s) Cell Biology and Immunology
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) plasmodium-falciparum malaria - c-reactive protein - alpha-thalassemia - clinical malaria - case definitions - endemic areas - children - morbidity - anemia - disease
Abstract Background It is controversial to what degree a+-thalassaemia protects against episodes of uncomplicated malaria and febrile disease due to infections other than Plasmodium. Methods In Tanzania, in children aged 6-60 months and height-for-age z-score <-1.5 SD (n = 612), rates of fevers due to malaria and other causes were compared between those with heterozygous or homozygotes a+-thalassaemia and those with a normal genotype, using Cox regression models that accounted for multiple events per child. Results The overall incidence of malaria was 3.0/child-year (1, 572/526 child-years); no differences were found in malaria rates between genotypes (hazard ratios, 95% CI: 0.93, 0.82-1.06 and 0.91, 0.73-1.14 for heterozygotes and homozygotes respectively, adjusted for baseline factors that were predictive for outcome). However, this association strongly depended on age: among children aged 6-17 months, those with a+-thalassaemia experienced episodes more frequently than those with a normal genotype (1.30, 1.02-1.65 and 1.15, 0.80-1.65 for heterozygotes and homozygotes respectively), whereas among their peers aged 18-60 months, a+-thalassaemia protected against malaria (0.80, 0.68-0.95 and 0.78, 0.60-1.03; p-value for interaction 0.001 and 0.10 for hetero- and homozygotes respectively). No effect was observed on non-malarial febrile episodes. Conclusions In this population, the association between a+-thalassaemia and malaria depends on age. Our data suggest that protection by a+-thalassaemia is conferred by more efficient acquisition of malaria-specific immunity
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