Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 418539
Title Composition of Human Skin Microbiota Affects Attractiveness to Malaria Mosquitoes
Author(s) Verhulst, N.O.; Qiu, Y.T.; Beijleveld, H.; Maliepaard, C.A.; Knights, D.; Schulz, S.; Berg-Lyons, D.; Lauber, C.L.; Verduijn, W.; Haasnoot, G.W.; Mumm, R.; Bouwmeester, H.J.; Claas, F.H.J.; Dicke, M.; Loon, J.J.A. van; Takken, W.; Knight, R.; Smallegange, R.C.
Source PLoS One 6 (2011)12. - ISSN 1932-6203 - 7 p.
DOI http://dx.doi.org/10.1371/journal.pone.0028991
Department(s) Laboratory of Entomology
Sub-department of Environmental Technology
Laboratory of Plant Breeding
PRI BIOS Applied Metabolic Systems
Laboratory of Plant Physiology
PE&RC
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) major histocompatibility complex - human axillary odor - anopheles-gambiae - mating preferences - aedes-aegypti - microflora - spectrometry - diversity - responses - selection
Abstract The African malaria mosquito Anopheles gambiae sensu stricto continues to play an important role in malaria transmission, which is aggravated by its high degree of anthropophily, making it among the foremost vectors of this disease. In the current study we set out to unravel the strong association between this mosquito species and human beings, as it is determined by odorant cues derived from the human skin. Microbial communities on the skin play key roles in the production of human body odour. We demonstrate that the composition of the skin microbiota affects the degree of attractiveness of human beings to this mosquito species. Bacterial plate counts and 16S rRNA sequencing revealed that individuals that are highly attractive to An. gambiae s.s. have a significantly higher abundance, but lower diversity of bacteria on their skin than individuals that are poorly attractive. Bacterial genera that are correlated with the relative degree of attractiveness to mosquitoes were identified. The discovery of the connection between skin microbial populations and attractiveness to mosquitoes may lead to the development of new mosquito attractants and personalized methods for protection against vectors of malaria and other infectious diseases
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