Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 419002
Title Polymer microspheres with structured surfaces
Author(s) Wagdare, N.A.; Baggerman, J.; Marcelis, A.T.M.; Boom, R.M.; Rijn, C.J.M. van
Source Chemical Engineering Journal 175 (2011)11. - ISSN 1385-8947 - p. 561 - 568.
Department(s) Laboratory for Organic Chemistry
Food Process Engineering
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) phase-inversion membranes - double-walled microspheres - controlled drug-release - polyethersulfone membranes - immersion precipitation - ppo membranes - blends - morphology - separation - emulsions
Abstract Microspheres from polymethyl methacrylate (PMMA) and Eudragit FS 30D (a commercial copolymer of poly(methyl acrylate-co-methyl methacrylate-co-methacrylic acid) 7:3:1) were prepared using microsieve emulsification. A mixture of these polymers in dichloromethane (DCM) was dispersed into water, leading to extraction of DCM in water and the formation of microspheres with a PMMA core and a partially demixed Eudragit shell. With a higher ratio of Eudragit to PMMA, more and bigger pores can be seen on the surface of the microspheres. Eudragit can be removed from the shell of the microspheres under alkaline conditions. Depending on the initial Eudragit to PMMA ratio, PMMA microspheres with different surface morphologies are obtained. At low Eudragit concentrations microspheres with a crumpled surface are formed, while at higher Eudragit concentrations microspheres are formed with a core to which dendritic PMMA structures are attached. At even higher Eudragit concentrations the microspheres obtained after dissolving the Eudragit show a nanorough surface.
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