Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 419341
Title Using simulation to estimate the power of a badger vaccine trial
Author(s) Aznar, I.; More, S.J.; Frankena, K.; Jong, M.C.M. de
Source In: Proceedings of the Society for Veterinary Epidemiology and Preventive Medicine, Leipzig, Germany, 23-25 March 2011. - - p. 111 - 123.
Event Society for Veterinary Epidemiology and Preventive Medicine, Leipzig, Germany, 2011-03-23/2011-03-25
Department(s) Quantitative Veterinary Epidemiology
WIAS
Publication type Contribution in proceedings
Publication year 2011
Abstract The aim of this study was to estimate the power of a badger vaccine field trial using simulation techniques. The effects of sample size, sensitivity and specificity of the diagnostic test, transmission rate between unvaccinated badgers, Vaccine Efficacy for Susceptibility (VES) and Vaccine Efficacy for Infectiousness (VEI) on study power were determined. The most striking result was the large effect of the specificity of the diagnostic test on study power. Sample size had a small effect on power. Study power increased with increasing transmission rate between non-vaccinated badgers. Changes in VES had a higher impact on power than changes in VEI. In summary, study power in group randomized trials depends not only on sample size but on many other parameters. In the current vaccine trial, power was highly dependent on the specificity of the diagnostic test. Therefore, it is critical that the diagnostic test used in the badger vaccine trial is optimized to maximise test specificity.
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