Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 419500
Title Linear and cyclic ester Oligomers of succinic acid and 1,4-butanediol: Biocatalytic synthesis and characterization
Author(s) Habeych Narvaez, D.I.; Eggink, G.; Boeriu, C.G.
Source Biocatalysis and Biotransformation 29 (2011)6. - ISSN 1024-2422 - p. 299 - 310.
DOI http://dx.doi.org/10.3109/10242422.2011.632478
Department(s) Bioprocess Engineering
FBR Bioconversion
FBR Sustainable Chemistry & Technology
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) enzyme-catalyzed synthesis - ring-opening polymerization - aliphatic polyesters - poly(butylene succinate) - organic media - epsilon-caprolactone - diethylene glycol - polyesterification - equilibrium
Abstract The lipase-catalyzed synthesis of cyclic ester oligomers from non-activated succinic acid (A) and 1,4-butanediol (B) in the presence of immobilized Candida antarctica lipase B was investigated. Batch and pulse fed-batch systems were implemented to increase the formation of cyclic ester products. The substrate conversions after 24 h were 86% and 95% under batch and fed-batch operation, respectively and the product of the reaction was, for both systems, a mixture of cyclic (CEOs) and linear (LEOs) ester oligomers. Fed-batch operation afforded a product containing 71% cyclic ester oligomers (CEOs) as compared with only 52% CEOs in batch operation. Cyclic ester oligomers accumulated as the reaction progressed, with the dimer CEO1 the most predominant product (i.e. 50% of the total products formed in fed-batch operation). The pulse fed-batch operation system was superior to the batch operation not only because higher substrate conversion and more CEOs were obtained, but also because it resulted in products with a higher degree of polymerization (DP up to 7). Cyclic ester oligomers are produced from the early stage of the reaction simultaneously with the linear ester oligomers by a ring-closure reaction on the active site of the enzyme, and not as a result of ring-chain equilibria
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