Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 419569
Title Genetic variants and the metabolic syndrome: a systematic review
Author(s) Povel, C.M.; Boer, J.M.; Feskens, E.J.M.
Source Obesity Reviews 12 (2011)11. - ISSN 1467-7881 - p. 952 - 967.
Department(s) Chair Nutrition and Disease
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) activated-receptor-gamma - coronary-heart-disease - polycystic-ovary-syndrome - body-mass index - insulin-resistance-syndrome - acid-binding protein-2 - apolipoprotein-c-iii - danish monica cohort - lamin a/c gene - pro12ala polymorphism
Abstract Several candidate gene studies on the metabolic syndrome (MetS) have been conducted. However, for most single nucleotide polymorphisms (SNPs) no systematic review on their association with MetS exists. A systematic electronic literature search was conducted until the 2nd of June 2010, using HuGE Navigator. English language articles were selected. Only genes of which at least one SNP–MetS association was studied in an accumulative total population =4000 subjects were included. Meta-analyses were conducted on SNPs with three or more studies available in a generally healthy population. In total 88 studies on 25 genes were reviewed. Additionally, for nine SNPs in seven genes (GNB3, PPARG, TCF7L2, APOA5, APOC3, APOE, CETP) a meta-analysis was conducted. The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. After having systematically reviewed the most studied SNP–MetS associations, we found evidence for an association with the MetS for eight SNPs, mostly located in genes involved in lipid metabolism
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