Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 419839
Title Coronary microvascular dysfunction in a porcine model of early atherosclerosis and diabetes
Author(s) Heuvel, M. van den; Sorop, O.; Koopmans, S.J.; Dekker, R.A.; Vries, R. de; Beusekom, H.M.M.; Eringa, E.C.; Duncker, D.J.; Danser, A.H.J.; Giessen, W.J.
Source American Journal of Physiology : Heart and Circulatory Physiology 302 (2012)1. - ISSN 0363-6135 - p. H85 - H95.
DOI https://doi.org/10.1152/ajpheart.00311.2011
Department(s) Livestock Research
Adaptation Physiology
LR - Backoffice
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) prediabetic metabolic syndrome - arterial resistance vessels - endothelial dysfunction - insulin-resistance - contractile responses - glucose-tolerance - s-nitrosothiols - risk-factors - blood-flow - mellitus
Abstract Detailed evaluation of coronary function early in diabetes mellitus (DM)-associated coronary artery disease (CAD) development is difficult in patients. Therefore, we investigated coronary conduit and small artery function in a preatherosclerotic DM porcine model with type 2 characteristics. Streptozotocin-induced DM pigs on a saturated fat/cholesterol (SFC) diet (SFC + DM) were compared with control pigs on SFC and standard (control) diets. SFC + DM pigs showed DM-associated metabolic alterations and early atherosclerosis development in the aorta. Endothelium-dependent vasodilation to bradykinin (BK), with or without blockade of nitric oxide (NO) synthase, endothelium-independent vasodilation to an exogenous NO-donor (S-nitroso-N-acetylpenicillamine), and vasoconstriction to endothelin (ET)-1 with blockade of receptor subtypes, were assessed in vitro. Small coronary arteries, but not conduit vessels, showed functional alterations including impaired BK-induced vasodilatation due to loss of NO (P <0.01 vs. SFC and control) and reduced vasoconstriction to ET-1 (P <0.01 vs. SFC and control), due to a decreased ETA receptor dominance. Other vasomotor responses were unaltered. In conclusion, this model demonstrates specific coronary microvascular alterations with regard to NO and ET-1 systems in the process of early atherosclerosis in DM. In particular, the altered ET-1 system correlated with hyperglycemia in atherogenic conditions, emphasizing the importance of this system in DM-associated CAD development.
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