Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 419920
Title Modeling growth, lipid accumulation and lipid turnover in submerged batch cultures of Umbelopsis isabellina
Author(s) Meeuwse, P.; Akbari, P.; Tramper, J.; Rinzema, A.
Source Bioprocess and Biosystems Engineering 35 (2012)4. - ISSN 1615-7591 - p. 591 - 603.
Department(s) Bioprocess Engineering
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) solid-state fermentation - oleaginous microorganisms - mortierella-isabellina - microbial lipids - cunninghamella-echinulata - mucor-circinelloides - biodiesel production - mathematical-model - chemostat model - fungi
Abstract The production of lipids by oleaginous yeast and fungi becomes more important because these lipids can be used for biodiesel production. To understand the process of lipid production better, we developed a model for growth, lipid production and lipid turnover in submerged batch fermentation. This model describes three subsequent phases: exponential growth when both a C-source and an N-source are available, carbohydrate and lipid production when the N-source is exhausted and turnover of accumulated lipids when the C-source is exhausted. The model was validated with submerged batch cultures of the fungus Umbelopsis isabellina (formerly known as Mortierella isabellina) with two different initial C/N-ratios. Comparison with chemostat cultures with the same strain showed a significant difference in lipid production: in batch cultures, the initial specific lipid production rate was almost four times higher than in chemostat cultures but it decreased exponentially in time, while the maximum specific lipid production rate in chemostat cultures was independent of residence time. This indicates that different mechanisms for lipid production are active in batch and chemostat cultures. The model could also describe data for submerged batch cultures from literature well.
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