Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 420128
Title Easily obtainable clinical features increase the diagnostic accuracy for later autoimmune diabetes in adults. An evidence based report
Author(s) Lutgens, M.W.M.D.; Meijer, M.; Peeters, B.; Poulsen, M.N.F.; Rutten, M.J.; Bots, M.L.; Heijden, G.J.M.G. van der; Soedamah-Muthu, S.S.
Source Primary Care Diabetes 2 (2008)4. - ISSN 1751-9918 - p. 207 - 211.
Department(s) Chair Nutrition and Disease
Publication type Refereed Article in a scientific journal
Publication year 2008
Abstract Background Latent autoimmune diabetes in adults (LADA) represents a subgroup of diabetes mellitus. LADA is characterised by adult-onset diabetes and circulating autoimmune antibodies. LADA patients may need a different therapeutic approach than the usual type 2 diabetes mellitus. When LADA is inadequately diagnosed as type 2 diabetes mellitus, LADA patients will mistakenly be exposed to a high dose of oral glucose lowering drugs and their possible side effects. Aim To assess which clinical features predict the presence or absence of LADA in patients older than 25 years presenting with hyperglycemia. Methods A structured Medline and Embase search was conducted. Titles and abstracts were screened using predetermined selection criteria. Critical appraisal was based on standardized validity criteria for diagnostic research. Results One-hundred and eighty-four papers were retrieved of which after assessment of relevance and validity 2 studies remained for further analysis. One study reported a probability of LADA of 0.99 with one or two out of the following five clinical features: age at onset
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