Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 420213
Title Intrinsic Aerobic Capacity Sets a Divide for Aging and Longevity
Author(s) Koch, G.; Kemi, O.J.; Qi, N.; Leng, S.X.; Bijma, P.; Gilligan, L.J.; Wilkinson, J.E.; Grevenhof, E.M. van
Source Circulation Research 109 (2011)10. - ISSN 0009-7330 - p. 1162 - 1172.
DOI http://dx.doi.org/10.1161/CIRCRESAHA.111.253807
Department(s) CVI Virology
Animal Breeding and Genetics
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) all-cause mortality - left-ventricular mass - exercise capacity - cardiorespiratory fitness - artificial selection - older-adults - risk-factors - cardiovascular-disease - physical-fitness - failing heart
Abstract Rationale: Low aerobic exercise capacity is a powerful predictor of premature morbidity and mortality for healthy adults as well as those with cardiovascular disease. For aged populations, poor performance on treadmill or extended walking tests indicates closer proximity to future health declines. Together, these findings suggest a fundamental connection between aerobic capacity and longevity. Objectives: Through artificial selective breeding, we developed an animal model system to prospectively test the association between aerobic exercise capacity and survivability (aerobic hypothesis). Methods and Results: Laboratory rats of widely diverse genetic backgrounds (N:NIH stock) were selectively bred for low or high intrinsic (inborn) treadmill running capacity. Cohorts of male and female rats from generations 14, 15, and 17 of selection were followed for survivability and assessed for age-related declines in cardiovascular fitness including maximal oxygen uptake (VO2max), myocardial function, endurance performance, and change in body mass. Median lifespan for low exercise capacity rats was 28% to 45% shorter than high capacity rats (hazard ratio, 0.06; P
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